Article | March 12, 2008

Compound Screening And Characterization Using Label-Free Interaction Analysis

08-Bioscience-SU_AsSeenIn.jpg

By Markku D. Hämäläinen, Senior Scientist in Chemometrics, and Fredrik Sundberg, Director of Strategic Market Development GE Healthcare

Surface plasmon resonance (SPR) detection could serve as a complement — or alternative — to high-throughput screening (HTS) in modern drug discovery.

The process of bringing new drugs successfully to market continues to present an enormous challenge. Despite recent significant investment in approaches such as high-throughput screening (HTS), attrition rates during later development phases remain high, resulting in costly failures. HTS involves the rapid analysis of very large compound libraries, but in many cases, the majority of hits identified are falsepositives and the compounds do not bind to the intended functional binding site on the target. Moreover, these are predominantly equilibriumbased assays that cannot deliver comprehensive binding data that may be highly relevant for the in vivo therapeutic performance of the drug. Adding to the challenge, some target classes (e.g. proteases), as well as particularly difficult individual drug targets (e.g. those with unknown or unstable functional partners), are unsuitable for HTS assays and require an alternative approach.
 

 

VIEW THE ARTICLE!
Signing up provides unlimited access to:
Signing up provides unlimited access to:
  • Trend and Leadership Articles
  • Case Studies
  • Extensive Product Database
  • Premium Content
HELLO. PLEASE LOG IN. X

Not yet a member of Biosimilar Development? Register today.

ACCOUNT SIGN UP X
Please fill in your account details
Login Information
I'm interested in newsletter subscriptions.
ACCOUNT SIGN UP

Subscriptions

Sign up for the newsletter that brings you the industry's latest news, technologies, trends and products.

You might also want to: