Newsletter | August 23, 2021

08.23.21 -- Continuous And Process Intensification Strategies To Maximize Productivity And Efficiency

Intensified And Improved Fed-Batch Production Process: High-Density N-1 Perfusion

Process intensification refers to strategies to maximize facility utilization and increase facility output. Although this commonly involves the design-in of continuous processing, the fed-batch culture is still predominant in stable protein production. The method described here allows you to intensify your fed-batch process through reduced production duration without affecting the growth or titer profile.

Intensified Chromatography Strategies

Major changes to the landscape of today’s industry are creating higher demands for flexible solutions that can minimize changeover time between campaigns. With a newer toolbox of options to intensify downstream manufacturing operations, it is important to understand what factors should impact decisions regarding the implementation of these solutions.

Buffer Management Solutions For Large-Scale Biomanufacturing

Buffer preparation is one of the most resource-intensive activities in biomanufacturing due to the large number of and overall volume of buffers and process liquids used in a typical bioprocess workflow. This article discusses how outsourcing buffers and technologies, such as inline conditioning and inline dilution, can help prevent resource constraints, save time, and reduce the manufacturing footprint and overall cost of buffer preparation.

Process Considerations For Closed Connected Processing

Closed connected processing poses new challenges with respect to process development, planning, and execution. By giving examples for the implementation of closed connected processing in large-scale manufacturing, this article will help you explore and assess options that work for your objectives.

Executing A Closed Connected Process From Start To Finish

Biomanufacturing is under increased pressure to adapt to market demands, such as reducing costs and bringing life-saving therapies to the people who need them faster. This article contains recommendations for the execution of a closed and connected monoclonal antibody (mAb) process, from design considerations to scale-up, including the small-scale modeling that directed a process at manufacturing scale.