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Are mild pH conditions not eluting your antibody from your resin? Are harsh pH conditions causing dimers and aggregates to form and co-elute with monomers? These issues could be leading to low monomer purity and recovery.
Some resins bind target biomolecules very tightly, compromising productivity. Screening multiple resins helps you select the one that provides the right balance of purity and recovery at mild elution conditions.
See how the Nuvia aPrime 4A provides the optimal balance of simultaneous yield and purity of the target mAb.
Click Here To View Detailed Technical Features of the Nuvia aPrime 4A Resin