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MabSelect SuRe™ LX

Source: GE Healthcare Life Sciences

MabSelect SuRe™ LX

MabSelect SuRe LX is an alkali-stabilized, protein A-derived affinity medium with a binding capacity for monoclonal antibodies (MAbs) exceeding that of MabSelect SuRe at longer residence times.

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Datasheet: MabSelect SuRe™ LX

MabSelect SuRe LX is an alkali-stabilized, protein A-derived affinity medium with a binding capacity for monoclonal antibodies (MAbs) exceeding that of MabSelect SuRe at longer residence times. As an example, at 6 min residence time, the dynamic binding capacity of MabSelect SuRe LX for human IgG is approximately 60 g/l. This special combination of high binding capacity plus alkaline stability gives manufacturers of MAbs many opportunities to improve process economics and product quality.

High dynamic binding capacity (DBC) helps users process feed from high-expression cell cultures with increased antibody titers in shorter time or with smaller chromatography unit operations. Enhanced alkaline stability means that regular cleaning-in-place (CIP) can be performed with cost-effective agents such as sodium hydroxide (NaOH) to prolong the medium’s working lifetime.

Key performance benefits of MabSelect SuRe LX include:

  • Outstanding binding capacity, for example, approx. 60 g/l medium for human IgG at 6 min residence time
  • Quick, efficient processing of large volumes of high-titer bioreactor feeds
  • Higher density eluates increase operating flexibility and allow smaller unit operations
  • Effective CIP with 0.1 M NaOH over hundreds of purification cycles improves process economy
  • Enhanced protease resistance of the protein A ligand reduces leakage
  • Generic elution conditions for different MAbs enable platform purifications

 

Medium characteristics well-established in bioprocessing

The MabSelect™ media family for the process-scale capture and purification of MAbs comprises MabSelect, MabSelect Xtra™, MabSelect SuRe, and MabSelect SuRe LX.

MabSelect SuRe LX has been further developed from MabSelect SuRe to give even higher binding capacity at longer residence time. Table 1 lists the main characteristics of MabSelect SuRe LX.

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Datasheet: MabSelect SuRe™ LX

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