White Paper

Managing Frozen Transport Logistics In The Biopharmaceutical Cold Chain

Source: Sartorius

By C├ędric Gentile and Katy McLaughlin

Cold chain iStock-1299794836

The enormous task of establishing a reliable infrastructure to supply COVID-19 vaccines across the globe has thrust cold chain shipping and its associated challenges into the spotlight. Valuable biologics, such as vaccines and recombinant therapeutic proteins, are often kept in a frozen state during storage and shipping. This requires robust solutions to ensure temperatures do not fluctuate and product integrity is preserved.

As biopharmaceutical manufacturing grows increasingly global, the production and transport networks required to keep operations running smoothly become more complex (1). Supply chains are further complicated by the trend towards decentralized production processes and the use of external contract manufacturing organizations (CMOs). The deviations associated with a complex production network can place strain on the frozen transport network.

Sartorius has extensive experience in designing and delivering innovative freeze/thaw solutions for the bioprocessing industry. Here, the authors provide a framework for making challenging decisions linked to cold chain management before outlining potential solutions that could solve many of the issues surrounding the frozen transfer of biopharmaceuticals.

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