Application Note

Stop Compromising Between High Yield And High Purity In Downstream Purifications

Source: Bio-Rad Laboratories, Inc.
pharm manufacturing

Mixed-mode resins are often used when unimodal resins fall short of providing the required process productivity and/or process economics. But not all mixed-mode resins are created equal. For example, the existing selection of available hydrophobic anion exchange resins provides either the needed yield or the needed purity, reducing process productivity either way.

To overcome this deficiency, Bio-Rad developed the Nuvia aPrime 4A Resin with an optimal balance of ion exchange and hydrophobic interactions to deliver simultaneous purity and yield of therapeutic proteins and monoclonal antibodies that are typically difficult to purify. Summarized below are the advantages provided by the Nuvia aPrime 4A Mixed-Mode Hydrophobic Anion Exchange Resin.