10.07.22 -- Time To Re-Think Your Buffer Management Strategy

We present different approaches to resolve buffer management challenges in large-scale biomanufacturing and discuss how outsourcing buffers and technologies, such as inline conditioning (IC) and inline dilution (ILD), can help prevent resource constraints, save time, and reduce manufacturing footprint and overall cost in buffer preparation.

Biomanufacturing requires large volumes of buffers, and preparation of these liquids can quickly become a bottleneck. Here, two options that can help intensify your large-scale buffer management are presented.

There is a limit to how many stainless-steel tanks you can squeeze into a biomanufacturing facility. Is automated buffer preparation a solution to the dilemma of balancing increased production capacity against limited footprint expansion alternatives?

The goal is to use the fewest steps possible to reliably manufacture a safe, effective, high-quality drug at a price point that makes sense. Doing so requires a deeper look at how to streamline operations to continuously achieve maximum utilization and reduce waste without sacrificing quality in the race to be first to market.