Application Note

Accurate Aliquoting Of Bulk Drug Substance Over A Range Of Product Viscosities And Target Weights

Source: Cytiva

By Natasha Kelly

Allegro Connect Bulk Fill System

Bulk filling drug substances in traditional facilities is often a lengthy, manual process where operators are relied upon to adjust pump controls to achieve accurate filling. This method, spanning multiple shifts, increases process risk through errors that can compromise accuracy. The Allegro Connect Bulk Fill System offers a solution as it can accurately fill up to 320 single-use biocontainer bags or bottles in an automated and sterile manner.

This system significantly reduces the risk of operator error and overall process time. It offers four configurations based on the type of filling container and quantity of containers needed. Moreover, the system allows for process flexibility to accommodate bioburden or sterile filtration in various configurations—single, serial, parallel, or none.

An automated 'recipe' controls the filling of each container, and adjusts the filling speed in a stepwise manner based on real-time container weight, eliminating the need for manual intervention during the filling process.

Here, we present bulk filling performance data generated from a series of application tests to demonstrate the reliability and consistency of the filling accuracy of the Allegro Connect Bulk Fill System within acceptable tolerances.

access the Application Note!

Get unlimited access to:

Trend and Thought Leadership Articles
Case Studies & White Papers
Extensive Product Database
Members-Only Premium Content
Welcome Back! Please Log In to Continue. X

Enter your credentials below to log in. Not yet a member of Biosimilar Development? Subscribe today.

Subscribe to Biosimilar Development X

Please enter your email address and create a password to access the full content, Or log in to your account to continue.


Subscribe to Biosimilar Development