ÄKTA avant™ Chromatography System

ÄKTA avant™ is a preparative chromatography system designed for rapid and secure development of scalable chromatographic methods and processes. ÄKTA avant™ offers a complete solution for rapid, high-quality protein separations while maintaining flexibility and reliability.

ÄKTA avant™ is a preparative chromatography system intended for method and process development. Available in two versions, ÄKTA avant™ systems have different flow rates and pressure specifications but share the same hardware setup. With flow rates up to 25 mL/min, ÄKTA avant™ 25 is designed for media screening and method optimization. ÄKTA avant™ 150, with flow rates up to 150 mL/min, is designed for scaling up to larger columns, as well as fine-tuning and robustness testing of the optimized process.. ÄKTA avant™ is operated by UNICORN™ 7 control software, which has been developed to increase productivity and efficiency. ÄKTA avant™ offers a complete solution for fast, high-quality protein separations while maintaining flexibility and reliability.

Speed: Increase productivity

• Maximal information from a minimal number of experiments with Design of Experiments (DoE) support integrated into UNICORN™ 7 software
• BufferPro automated online buffer preparation together with a quaternary valve enables quick and easy preparation of single buffers as well as screening for optimal buffer compositions, including pH scouting
• Ease-of-use in every detail

Security: reliable results with complete sample security and regulatory compliance

• Ensure sample integrity by contaminant-protected and cooled, integrated fraction collector
• Work faster while meeting regulatory requirements for 21 CFR part 11 and use of electronic signatures
• Easily trace column run data history with UniTag scanning
• Column protection via flow regulation controlled by differential pressure measurement

Scalability: achieve direct, dependable scalability while systematically anticipating errors

• Automatic conversion of UNICORN™ 7 methods when scaling up and down between the two ÄKTA avant™ versions
• Take full advantage of modern high flow rate BioProcess™ media such as MabSelect™ and Capto™ resin families
• Scale quickly and predictably from screening and method optimization using HiScreen™ columns to finetuning and robustness testing on AxiChrom™ columns
• Intelligent packing of AxiChrom™ columns (50 to 70 mm inner diameter) supported by ÄKTA avant™ 150 system for fast reproducible column packing every time