In medicine, the biggest hurdle is getting the active pharmaceutical ingredient (API) into the target cells at the disease site, referred to as the drug delivery challenge. Nucleic acid drugs in particular face many hurdles in their journey from vial to the cytoplasm of target cells where they are active. Hydrolysis, ubiquitous nucleases, the host’s immune system, trafficking within the body, cellular uptake and release into the cytoplasm all impact the safety and efficacy of nucleic acid drugs.
Lipid nanoparticles (LNPs) function as a drug delivery system (DDS) for nucleic acids as it protects the cargo from degradation and mediates a targeted, safe, and efficient intracellular delivery. Learn about biomedical applications of lipid nanoparticles (LNPs), anatomy of LNPs, formulation optimization, and LNP safety.