CHT™ Ceramic Hydroxyapatite XT Media

Introduction

CHT Ceramic Hydroxyapatite Media is a spherical, macroporous form of hydroxyapatite that has been sintered at high temperatures to yield a physically and chemically robust support. It is ideal for large-scale bioprocess applications, providing consistent results at scales of at least 1.8 meters. CHT Ceramic Hydroxyapatite provides unique separation properties along with unmatched selectivity and resolution. It can be used in applications such as purification of enzymes, monoclonal and polyclonal antibodies of various classes, antibody fragments, and bispecific antibodies; efficient isolation and purification of viruses and virus-like particles (VLPs); and separation of supercoiled DNA from linear duplexes as well as single stranded from double-stranded DNA.

High Stability and Unique Selectivity

CHT Ceramic Hydroxyapatite XT Media (CHT XT) is the latest addition to the existing line of ceramic hydroxyapatite media encompassing CHT Type I and Type II. The technical features of CHT XT are listed in Table 1. It is designed to provide added robustness and lifetime. The chemical composition of CHT XT is (Ca₁₀(PO₄)₆(OH)₂) and it is a mixed-mode media .Biomolecules can interact with CHT through calcium affinity interactions and/or cation exchange interactions. Please refer to the CHT Applications Guide (bio-rad.com/CHTGuide) for details on both these interactions.

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