MabSelect™ VL Protein L Resin

MabSelect™ VL resin with a redesigned protein L ligand for high binding capacity and improved alkaline stability. For affinity capture of antibody Fabs, bispecifics, and other variants containing a kappa light chain.

• High dynamic binding capacity protein L resin for efficient capture of antibody Fabs, bispecifics, and variants containing a kappa light chain.
• Stable when cleaned with 0.1 M NaOH, reducing risk for bioburden incidents.
• Provides good resolution for product-related impurities in the capture of bispecific antibodies.

Built for a diversifying pipeline

As the diversity of antibody variants increases, so does the need for chromatography resins that can capture and purify these variants. As an alternative to protein A, protein L resin can be used to capture antibody Fabs, bispecific antibodies, and other molecules containing kappa variants of the variable light (VL) chain. Protein L binds human kappa light chain subtypes 1, 3, and 4 and mouse kappa light chain subtype 1.

Redesigned protein L ligand

MabSelect™ VL resin showed a two-fold increase in binding capacity compared to our Capto™ L chromatography resin. This higher capacity provides productivity advantages in research and biomanufacturing.

MabSelect™ VL resin can withstand cleaning with 0.1 M NaOH, thanks to multimerization and modification of one of the domains of the native protein L ligand.

MabSelect™ VL protein L resin is also available in 1 mL and 5 mL HiTrap™ prepacked columns for use in research applications,  PreDictor™ RoboColumn® minicolumns for convenient method optimization and parameter screening in process development, and as prepacked ReadyToProcess™ columns.