Application Note

Real-Time And In-Line Raman Spectroscopy: A Window Into Glycosylation Quality Analysis


Inadequate control of glycosylation profiles in bioprocessing can significantly alter biological activity, pharmacokinetics, immunogenicity, and cellular recognition of proteins, posing substantial risks. Therefore, bioprocess engineers must ensure the efficiency, safety, and regulatory compliance of monoclonal antibodies (mAbs) used in patient treatments. Raman spectroscopy has proven its ability to provide non-invasive, real-time information, making it a valuable tool for quantitative glycan analysis. Additionally, it shows great potential for automated process control in glycan analysis.

This study details the use of in-line Raman spectroscopy to monitor monoclonal antibody (mAb) glycan profiles within a production bioreactor. It highlights the potential for Raman technology to enhance process control automation and customization regarding glycosylation patterns in mAb production.

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