Single-Use, Automated Depth Filtration System: Allegro™ Connect

The Allegro™ Connect Depth Filtration System is a single-use automated filtration system designed to deliver robust process control during the clarification/harvest step.

• Automatically performs pre-use water flushing, product filtration, and buffer chase – utilizing standard manifolds
• Filters up to 2000 L* of process stream from a bioreactor scale
• Supports a total of 30 m² first stage, 20 m² second stage installed filter chassis, and up to 2 × 762 mm (30 in.) in-line bioburden reduction filters installed on the system cabinet to reduce footprint
• Combined manifold and installed filter leak test to ensure a correctly assembled flow path with no leaks prior to application of process fluid
• Electronic batch records (summary and detailed), compiling data from the single-use sensors within the flow path and other critical process parameters
• Common automation software (Wonderware-based) used across the Allegro Connect range, which aids ease of recipe creation and operator usability
• A complete single-use flow path can be installed or uninstalled by a single operator in < 90 minutes

* Larger volumes may be possible for less challenging process streams