Small-Scale GMP Manufacturing With ÄKTA ready™ Chromatography System 450

To meet the needs of purifying small drug volumes, the system has a low flow range of 5 to 450 mL/min per pump and a low hold-up volume. The single-use flow path minimizes the need for cleaning and cleaning validation, allowing for quick changeover between productions and reducing the risk of carryover.

Designed for small-scale manufacturing:

• Small hold-up volume and flow rate support efficient purification of small drug volumes.
• Gamma-irradiated single-use closed flow path reduces contamination risk and cleaning validation efforts. Option for aseptic connectors.
• Multi-wavelength UV detection and low shear pump support purification of viral vectors and other sensitive biomolecules.
• Small benchtop footprint makes efficient use of valuable facility space.