Developing combination products and devices to better the user experience is an ever-present challenge for the healthcare industry. There may be many benefits of self-administration systems, such as fewer hospital visits/lower costs, improved quality of life, and better patient compliance. However, drug manufacturers may select traditional drug containment systems, such as vials, to avoid the burden of meeting regulatory requirements for new delivery devices or because they lack the expertise production developing combination products. In order to meet the evolving needs of patients, life-saving device innovations are needed for the next generation of delivery devices. As drug manufacturers explore the device world, human factors should be a key consideration.