Biosimilar App Notes & Case Studies

  1. Multidimensional Scale-Up Of A mAb Capture Step Contributes To Shortened Time To Market
    10/10/2018

    This application note demonstrates a multidimensional scale-up (change of both column diameter and bed height) of a mAb capture step, using the ÄKTA pilot 600 chromatography system.

  2. Doubling Up For Speed: Using Parallel Operations In Biopharma Manufacturing
    6/21/2018

    One solution to drug development challenges is adopting a parallel operations business model. This article offers recommendations for how parallel operations can be leveraged in a biomanufacturing strategy.

  3. Amgen’s Digital Transformation: Link Suppliers' Raw Material Data To Patients
    10/19/2018

    Using its Supplier Relationship Excellence program, Amgen opened the lines of communication with suppliers and created a feedback loop where data can be shared to optimize operational performance. 

  4. Non-Affinity Chromatography Resin Alternative For Capture Purification Of Antibodies
    1/10/2019

    Protein A affinity purification has multiple limitations in terms of productivity at manufacturing scale and the costs associated with making commercial antibodies, especially biosimilars.