Biosimilar App Notes & Case Studies
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Extractables In Single-Use Systems Used In ADC Manufacturing
9/23/2024
To address concerns about using organic solvents in the ADC process, extractables studies were conducted on a disposable chromatography column housing and two different disposable flow paths.
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Accelerating The mAb Formulation Process
5/7/2024
Learn about a one-step process that was developed to streamline formulation, effectively reducing timelines from approximately 14 weeks to 8 weeks for this critical step.
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Optimizing TFF And SPTFF For High-Concentration mAb Formulations
4/9/2025
Discover the critical role of formulation buffer composition in stabilizing monoclonal antibodies during tangential flow filtration, a process involving ultrafiltration and diafiltration under high pressure and shear forces.
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Real-Time And In-Line Raman Spectroscopy For Glycan Quality Analysis
6/14/2024
This study details the use of in-line Raman spectroscopy to monitor mAb glycan profiles within a production bioreactor, highlighting its potential for automation and customization.
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Using Automated Spinoculation For CAR T Cell Lentiviral Transduction
2/26/2024
There is a growing demand for closed and automated lentiviral transduction steps in CAR T cell therapy workflows. Learn about a potential solution to address this unmet need.
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Implementation Of Multi-Column Chromatography Systems
4/4/2025
Discover how a multi-column chromatography system enhances resin utility and enables continuous bioprocessing with minimal surge tankage for agile multi-product facilities.
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Enabling Accelerated Raman Model Calibration For Real-Time Monitoring
6/14/2024
Raman spectroscopy is a key component of a PAT strategy. Evaluate an innovative workflow designed to streamline the integration of an in-line Raman analyzer for bioreactor applications.
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Optimizing The Formulation For A Monoclonal Antibody
8/21/2023
An emerging biotech company sought help developing a formulation for a monoclonal antibody. Explore how MilliporeSigma delivered an optimized formulation within an aggressive timeline and budget.
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Developing A Large-Scale Tangential Flow Filtration Process
5/13/2024
Discover a process that can be modified to fit your downstream process and serves as a complete solution for concentration and diafiltration.
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Adapting Single-Use Chromatography To Manufacturing Scale
5/16/2024
Explore strategies for accommodating the ever-increasing upstream titers and volumes to prevent downstream purification from becoming a bottleneck.