Biosimilar App Notes & Case Studies

41. Process-Economy Simulation Of mAb Capture Step With Protein A Chromatography Resin 10/10/2018

    Calculation examples that highlight scenarios where the enhanced capacity and alkaline‑stability of MabSelect PrismA can provide process economic benefits to large‑scale mAb processing.

42. Best Practices For A Successful Bioprocess Technology Transfer 9/10/2019

    A well-executed bioprocess technology transfer is critical to ensure smooth knowledge transfer and optimal process reproducibility. 

43. Automated High Throughput mAb Purification Using Fibro Technology 4/21/2020

    Biomanufacturing is trending towards higher numbers of monoclonal antibody (mAb) projects and smaller batch sizes, with production of most mAbs below 100 kg/yr. These trends are fueling demands to screen more clones faster and improve the efficiency of process development (PD). Read how the Fibro PrismA unit provides a time advantage with comparable recovery and product quality attributes to resin-based column.

44. Embracing Biosimilars, They Are Here To Stay 10/10/2018

    The biosimilars market is suddenly booming, with established biopharma giants and nimble start-ups all clamoring for a piece of the action. But such steep competition means that only the wise will survive.

45. Rapid, Sensitive Cancer Biomarker Screening In cfDNA 10/4/2018

    Multiplex digital PCR enables tracking of treatment efficacy using liquid biopsies.

46. Can A Shared Biomanufacturing Facility Be The Answer To The Demand Forecasting Dilemma? 8/13/2018

    Using a shared biomanufacturing facility, a biomanufacturer can minimize its investment while mitigating the risks of demand uncertainty and maximizing time to market.

47. An End-To-End, Semi-Continuous Process For mAb Production 9/22/2019

    See how the different unit operations in a laboratory-scale monoclonal antibody (mAb) process can be connected and integrated into a semi-continuous process.

48. Downstream Process Development For Efficient Purification Of Adenovirus 9/10/2018

    Here, we describe the development of two effective downstream processes for purification of adenovirus from cell culture harvest.

49. Improved Process Economics Of Humira Biosimilar Purification 1/10/2019

    This application note proposes an alternate but equally effective approach to biosimilar purification, by substituting a less expensive ion exchange resin for the affinity capture step.

50. Purification Of An Acidic IgM For Large Biomolecule Purification 1/10/2019

    The large size of IgMs makes their purification very challenging. See how Bio-Rad's new strong anion exchange resin (AEX), Nuvia HP-Q, has the ability to overcome the multiple issues faced when purifying large biomolecules.