Featured Articles

31. Fueling The Genetic Revolution With cGMP Manufacturing And Training 5/20/2022

    ElevateBio, in collaboration with Cytiva, is forging a path forward with a solution to de-risk the development of novel therapies, helping to speed the delivery of new CGTs and regenerative medicines.

32. Automated Bag Thawing System For CAR-T Cell Therapy Manufacturing 1/11/2022

    The performance of the VIA Thaw CB1000 is compared to thawing in a water bath. The VIA Thaw™ dry thawing system shows comparable performance to a water bath with less handling.

33. Scalable AAV Purification Process For Gene Therapy 11/22/2021

    Processes to produce AAV for gene therapies are in place, but there’s room to optimize purification to achieve high overall yields and efficiently remove empty capsids and other impurities.

34. Process Development For AAV Vector Production In Suspension Cells 11/19/2021

    Review experiments for the adaptation of the HEK293 suspension cell line for transient transfection and scalable adeno-associated virus (AAV) production.

35. Adeno-Associated Virus (AAV) Production Using Microcarriers 6/2/2021

    After comparing adherent, suspension, and microcarrier culture for AAV production, scientists believe microcarrier culture is suitable for production of viral vectors to support gene therapy manufacturing.

36. Shipping Temperatures For Cell Therapies 5/14/2021

    Cryopreserved cells are often stored at a central facility before being shipped to the clinical location. This study explores the required shipping and storage temperatures for cryogenic cold chain delivery of biological samples.

37. Overcoming Cell Therapy Supply Chain Challenges 5/11/2021

    For the industry to realize the potential of cell and gene therapies (CGTs), we must develop improved solutions that reliably support the control and transport of critical CGT raw materials and products.

38. Consistency And Compliance: Cell Therapy Automation Software 4/30/2021

    Automation offers new options for flexibility and optimized biologic production, improving safety, quality, and compliance while advancing patient care.

39. The Science Of Cell Therapy Thawing 4/5/2021

    A summary of the science of thawing following conventional slow freezing methods, the physical and biological implications of key metrics and components, and key studies from scientific literature.

40. Preparing For Future Viral Vector Manufacturing Technologies And Platforms 3/1/2021

    Rethinking how we transition from translational clinical centers at smaller scale—using flasks and open systems—towards commercial production and methodologies.