product datasheets, catalogs, app notes

  1. Series 4000™ Single-Round Filter Housings Datasheet 10/5/2020

    The Series 4000™ single-round filter housing line provides a range of pre-configured designs to meet all your process and filtration needs. It is available in T-Line and In-Line designs, with a wide range of tube sizes.

  2. Mobius® Chrom 20 System Datasheet 10/5/2020

    The Mobius® Chrom 20 system is a flexible, automated, single-use chromatography system that enables consistent and reliable separation and purification of mAbs, vaccines, plasma, and therapeutic proteins at clinical and process scales.

  3. pDADMAC Flocculant Reagent For Use With Clarisolve® Depth Filters 8/17/2020

    Clarisolve® depth filter with pDADMAC flocculant pretreatment demonstrates a significant improvement in filtration efficiency, including a reduction in supernatant turbidity and improved volumetric throughput compared to conventional filters. The purification process removes the residual polymer to a concentration less than 1 ppm, where it showed no in vitro cytotoxicity and hemolytic concerns, and could be used as a reasonable target for acceptable polymer clearance. Overall, pDADMAC treatment in combination with Clarisolve® depth filters provides an effective solution for harvesting high-cell-density cultures and can be easily incorporated into current clarification platforms.

  4. High Temperature Short Time (HTST) Treated Glucose 8/17/2020

    HTST pasteurization is a highly effective method to inactivate viruses. It involves the rapid heating of the material to a predetermined temperature (>100 °C) and holding it at that temperature for a specified time to inactivate adventitious viral agents that may be present. This technology has been typically used as an in-house treatment for high risk bioreactor feeds, such as glucose, and is becoming an integral part of many biopharmaceutical companies’ viral risk-mitigation strategies.

  5. Cellicon™ Perfusion Filter and Controller Data Sheet 8/7/2020

    The benchtop Cellicon™ Perfusion Solution is designed to meet your perfused seed train challenges. It consists of a controller and a flat sheet cell retention filter with a single-use assembly running in tangential flow filtration mode. This easy‑to‑use solution increases perfusion process efficiency, and provides real-time monitoring and control for reliable and consistent performance.

  6. Novel Cell Retention Tech, Cell Culture Media For N-1 Perfused Seed Train 7/19/2020

    Perfusion operations deliver high density cell cultures that alleviate the burden of processing large production bioreactor volumes while increasing manufacturing flexibility.

  7. Blazar Platform: Rodent Virus Panel 7/15/2020

    By amplifying multiple targets within a conserved region of the viral family genome, Blazar detects a much broader range of adventitious viruses as compared to traditional polymerase chain reaction methods.

  8. Eshmuno® CMX — A Novel Mixed Mode Cation Exchange Resin For The Purification Of Glycoproteins 6/29/2020

    With the outbreak of COVID-19, the most severe pandemic in the 21st century so far, a feverish search for therapeutic treatment and vaccinations has just started. A substantial number of approaches are focusing on the coronavirus S glycoprotein, a surfaceexposed protein that mediates the entry of the virus into the host cells. The aim of this technical note is to provide a description of the capture and subsequent purification of glycoproteins.

  9. ADC Separation: Mixed Mode Cation Exchange Chromatography In A mAb Process 6/18/2020

    This application note describes the steps followed and considerations taken during the development of antibody drug conjugate separation using a mixed mode cation exchange chromatography step.

  10. Eshmuno® CMX Chromatography Resin Data Sheet 6/18/2020

    Eshmuno® CMX chromatography resin is a highly selective mixed mode chromatography resin for difficult to purify mAbs, ADCs and fusion proteins. This innovative resin combines weak cation exchange properties with hydrophobic interaction, providing high selectivity for mAb, fusion protein and ADC purification as well as separation of low molecular weight impurities and Host Cell Proteins (HCPs).