product datasheets, catalogs, app notes
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Optimization Strategy And Process Economics Of DNA Digestion In Viral Vector Production For Gene Therapy
12/16/2020
Benzonase® endonuclease is a high-quality product delivering immense value to viral vector processes. The enzyme activity is strongly influenced by the matrix, and optimization of its use should be a mandatory step in process development. In this application note, we highlight an optimization strategy and process economics of DNA digestion in viral vector purification.
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Integritest® 5: Integrity Assurance With Ease And Confidence Datasheet
11/12/2020
Accurately and reliably verify the integrity of your filters and processing equipment with the portable, easy to implement, and automated Integritest® 5. The Integritest® 5 delivers a simple and intuitive user experience, while providing optional depth of flexibility to fit your process.
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Bubble Point Testing With Integritest® 5
11/12/2020
During a bubble point test, pressure decay measurements are taken at increasing applied transmembrane pressures to map the filter’s integrity profile. The Integritest® line of automated integrity testing instruments identifies optimum pressures at which to take measurements based on test parameters and ongoing readings, which reduces the number of measurements needed to reliably map the filters’ profile and return an accurate result.
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Automation For Integritest® 5
11/12/2020
The IT5's automation features allow for real-time communication and control of the instrument through secure OPC UA (Open Platform Communications united Architecture) communication, ensuring reliability and security for filter integrity testing.
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Redesigned Filter Capsule Improves Final Filtration Assembly Design And Operation
11/3/2020
In final filtration and filling operations, where maintaining sterility is critical to assuring drug safety for patients, sterilized single-use assemblies offer many advantages. This application note describes testing performed to assess volume loss in SURF assemblies and shows how both assembly design and filtration operations can be adapted to minimize volume and product loss in the system.
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How Pattern Search Finds Anomaly Patterns In Historical Machine Data
10/21/2020
Owing to the sheer volume of data streaming from sensor profiles, anomalies observed during process monitoring in historical data are extremely difficult to search due to a lack of time series search tools.
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Next-Gen Bioprocess Monitoring: Smart Data Management And Analysis
10/14/2020
A new platform that includes digital technologies/data management, process analytical technologies and intensified processing will drive next generation bioprocessing.
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Series 4000™ Single-Round Filter Housings Datasheet
10/5/2020
The Series 4000™ single-round filter housing line provides a range of pre-configured designs to meet all your process and filtration needs. It is available in T-Line and In-Line designs, with a wide range of tube sizes.
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Mobius® Chrom 20 System Datasheet
10/5/2020
The Mobius® Chrom 20 system is a flexible, automated, single-use chromatography system that enables consistent and reliable separation and purification of mAbs, vaccines, plasma, and therapeutic proteins at clinical and process scales.
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pDADMAC Flocculant Reagent For Use With Clarisolve® Depth Filters
8/17/2020
Clarisolve® depth filter with pDADMAC flocculant pretreatment demonstrates a significant improvement in filtration efficiency, including a reduction in supernatant turbidity and improved volumetric throughput compared to conventional filters. The purification process removes the residual polymer to a concentration less than 1 ppm, where it showed no in vitro cytotoxicity and hemolytic concerns, and could be used as a reasonable target for acceptable polymer clearance. Overall, pDADMAC treatment in combination with Clarisolve® depth filters provides an effective solution for harvesting high-cell-density cultures and can be easily incorporated into current clarification platforms.