product datasheets, catalogs, app notes

81. Cellvento® 4CHO Fed-batch Medium 4/26/2021

    Different CHO hosts are used routinely to develop such biologics and are combined with several expression system like the dhfr, the UCOE or the glutamine synthetase (GS) system. The platform described in this process guidance was developed to grow a broad range of CHO cells. The production medium supports initial cell growth and production while the highly concentrated, neutral pH feed is added to replenish depleted nutrients required for cellular function and to maintain and extend the production phase in fed-batch mode.

82. 1X PBS (Phosphate Buffered Saline) Buffer Mixing Optimization 4/23/2021

    This study develops optimal process conditions for mixing and filtering of 1X PBS buffer using the 50 L, 200 L, and 1000 L Mobius® Single-Use Mixing Solution, Durapore® and Millipore Express® filters.

83. Blazar® Platform: Rodent Virus Panel From The BioReliance® Portfolio 3/12/2021

    Did you know about the alternative rapid method for in vivo MAP/HAP/RAP testing? Download our tech note Blazar® Platform: Rodent Virus Panel From The BioReliance® Portfolio to learn more about our novel degenerate PCR assay designed for the detection of a broad range of adventitious agents.

84. Optimization Strategy And Process Economics Of DNA Digestion In Viral Vector Production For Gene Therapy 12/16/2020

    Benzonase® endonuclease is a high-quality product delivering immense value to viral vector processes. The enzyme activity is strongly influenced by the matrix, and optimization of its use should be a mandatory step in process development. In this application note, we highlight an optimization strategy and process economics of DNA digestion in viral vector purification.

85. Integritest® 5: Integrity Assurance With Ease And Confidence Datasheet 11/12/2020

    Accurately and reliably verify the integrity of your filters and processing equipment with the portable, easy to implement, and automated Integritest® 5. The Integritest® 5 delivers a simple and intuitive user experience, while providing optional depth of flexibility to fit your process.

86. Bubble Point Testing With Integritest® 5 11/12/2020

    During a bubble point test, pressure decay measurements are taken at increasing applied transmembrane pressures to map the filter’s integrity profile. The Integritest® line of automated integrity testing instruments identifies optimum pressures at which to take measurements based on test parameters and ongoing readings, which reduces the number of measurements needed to reliably map the filters’ profile and return an accurate result.

87. Automation For Integritest® 5 11/12/2020

    The IT5's automation features allow for real-time communication and control of the instrument through secure OPC UA (Open Platform Communications united Architecture) communication, ensuring reliability and security for filter integrity testing.

88. Redesigned Filter Capsule Improves Final Filtration Assembly Design And Operation 11/3/2020

    In final filtration and filling operations, where maintaining sterility is critical to assuring drug safety for patients, sterilized single-use assemblies offer many advantages. This application note describes testing performed to assess volume loss in SURF assemblies and shows how both assembly design and filtration operations can be adapted to minimize volume and product loss in the system.

89. How Pattern Search Finds Anomaly Patterns In Historical Machine Data 10/21/2020

    Owing to the sheer volume of data streaming from sensor profiles, anomalies observed during process monitoring in historical data are extremely difficult to search due to a lack of time series search tools. 

90. Next-Gen Bioprocess Monitoring: Smart Data Management And Analysis 10/14/2020

    A new platform that includes digital technologies/data management, process analytical technologies and intensified processing will drive next generation bioprocessing.