product datasheets, catalogs, app notes

81. How Millipak® Barrier And Millidisk® Barrier Filters Streamline Final Sterile Filtration 8/3/2021

    Millipak® Barrier and Millidisk®  Barrier filters contain hydrophilic and hydrophobic sterilizing-grade Durapore® 0.22 μm membrane. As they allow the passage of both liquid and air, they can be used to simplify wetting and drying during integrity testing of sterilizing filters. Learn more about the benefits of these filters and some guidance for implementation.

82. Single-Use Per Batch Biomolecule Purification Chromatography Membrane 7/20/2021

    Explore the performance of an advanced chromatography membrane when compared to currently available quaternary amine resins, membranes, and salt-tolerant primary amine membranes.

83. Pellicon 3 Cassettes Cleaning Methodology 7/13/2021

    This study demonstrates efficient cleaning strategies to enable multiple reuse of TFF cassettes for high concentration applications with SPTFF.

84. Comparison Between Experimental Data And Computational Fluid Dynamics In Mixing Applications 7/9/2021

    In biomanufacturing processes, mixing is ubiquitous and mixing trials are often necessary to assess if a technical solution is adapted for a given process step or to optimize process parameters. Discover how computational fluid dynamics can help in your mixing trials.

85. Cell Culture Media Mixing And Microfiltration: Reducing Risk With Single-use Technology 6/11/2021

    Cell culture media are complex mixtures of synthetic and biological components that provide the proper composition of nutrients for healthy cell propagation and high protein expression. Key concerns are to ensure product safety and purity. This paper presents our recommended methods for thoroughly mixing media, as well as reducing the risk of mycoplasma contamination.

86. Demonstrating Millipore Express® SHR Mycoplasma Clearance 6/9/2021

    Millipore Express® SHR filters are an option for biomanufacturers looking for a higher level of microbial risk reduction than sterilizing-grade filters. These filters contain a 0.1 μm polyethersulfone (PES) sterilizing membrane and are designed to efficiently remove mycoplasma contaminants from cell culture media.

87. The Effect Of Mixing On Protein Using Mobius® Mixers 6/7/2021

    To address broad biomanufacturing mixing applications, we offer two distinct lines of single-use mixers with common attributes. Depending on individual manufacturing set-ups and organizations, mixing equipment may have to be used without distinction for all applications. This application note explores the suitability of the different Mobius® mixer types for various model feeds.

88. Cellvento® 4CHO Fed-batch Medium 4/26/2021

    Different CHO hosts are used routinely to develop such biologics and are combined with several expression system like the dhfr, the UCOE or the glutamine synthetase (GS) system. The platform described in this process guidance was developed to grow a broad range of CHO cells. The production medium supports initial cell growth and production while the highly concentrated, neutral pH feed is added to replenish depleted nutrients required for cellular function and to maintain and extend the production phase in fed-batch mode.

89. 1X PBS (Phosphate Buffered Saline) Buffer Mixing Optimization 4/23/2021

    This study develops optimal process conditions for mixing and filtering of 1X PBS buffer using the 50 L, 200 L, and 1000 L Mobius® Single-Use Mixing Solution, Durapore® and Millipore Express® filters.

90. Blazar® Platform: Rodent Virus Panel From The BioReliance® Portfolio 3/12/2021

    Did you know about the alternative rapid method for in vivo MAP/HAP/RAP testing? Download our tech note Blazar® Platform: Rodent Virus Panel From The BioReliance® Portfolio to learn more about our novel degenerate PCR assay designed for the detection of a broad range of adventitious agents.