Biosimilar App Notes & Case Studies

31. Rapid, Sensitive Cancer Biomarker Screening In cfDNA 10/4/2018

    Multiplex digital PCR enables tracking of treatment efficacy using liquid biopsies.

32. Adenovirus Production In Single-Use Xcellerex™ XDR-10 Bioreactor System 9/10/2018

    This application note describes the production of adenovirus in HEK293 cells cultured in HyClone™ CDM4HEK293 culture medium.

33. Optimization Of Midstream Cell Lysis And Virus Filtration Steps In An Adenovirus Purification Process 9/10/2018

    Here we describe screening of detergents for release of adenovirus from HEK293 host cells to replace the traditionally used detergent Triton™.

34. Can A Shared Biomanufacturing Facility Be The Answer To The Demand Forecasting Dilemma? 8/13/2018

    Using a shared biomanufacturing facility, a biomanufacturer can minimize its investment while mitigating the risks of demand uncertainty and maximizing time to market.

35. Epitope Binning: A Critical Step In Antibody Selection 1/31/2020

    Epitope binning immunoassays using surface plasmon resonance (SPR) can and should be deployed in the development of new potential drug candidates. This article discusses how SPR is used to characterize closely related “bins” of mAbs targeting the same epitope of the target protein and how the selection process is used to develop new vaccines, therapeutic antibodies, and diagnostic tools.

36. The Past And Future Of Managing Raw Material And Process Risks In Biomanufacturing 9/18/2018

    How far have we come in raw material supply management, and what still needs accomplished to ensure the delivery of safe and effective drugs?

37. Protein Thermal Shift Assays Made Easy 4/8/2020

    Protein thermal shift assays enable quick and easy buffer optimization for increased protein stability. Learn more about the CFX Real-Time PCR Detection Systems which uses a simple protocol to measure protein thermal stability using SYPRO Orange Fluorescent Dye.

38. Use Of Sodium Hydroxide For Cleaning And Sanitization Of Chromatography Resins And Systems 10/2/2018

    This application note examines these aspects of using sodium hydroxide as a cleaning and sanitizing agent.

39. Embracing Biosimilars, They Are Here To Stay 10/10/2018

    The biosimilars market is suddenly booming, with established biopharma giants and nimble start-ups all clamoring for a piece of the action. But such steep competition means that only the wise will survive.

40. Capacity And Performance Of MabSelect™ PrismA Protein A Chromatography Resin 10/2/2018

    This application note demonstrates the binding capacity of MabSelect PrismA in comparison with its predecessor products for both polyclonal and monoclonal antibodies.