Biosimilar App Notes & Case Studies

  1. Investigating The Important Parameters For Packing Nuvia HR-S Resin At Process Scale 5/27/2020

    Process-scale production typically involves more than one column. The packing quality of each column affects the efficiency of the whole workflow and is an important validation criterion. Here, we investigate the effects of packing methods, packing solutions, compression factor, resin slurry concentration, and bed height on the efficiency of packed columns.

  2. Adenovirus Production In Single-Use Xcellerex™ XDR-10 Bioreactor System 9/10/2018

    This application note describes the production of adenovirus in HEK293 cells cultured in HyClone™ CDM4HEK293 culture medium.

  3. Fujifilm Diosynth Biotechnologies Drives Flexibility And Efficiency In Their Biomanufacturing Platform Using Integrated Automation 8/30/2018

    Through a successful implementation, Fujifilm was able to not only recognize the benefits an integrated automation platform offers but also the importance of working with an experienced partner.

  4. Doubling Up For Speed: Using Parallel Operations In Biopharma Manufacturing 6/21/2018

    One solution to drug development challenges is adopting a parallel operations business model. This article offers recommendations for how parallel operations can be leveraged in a biomanufacturing strategy.

  5. Determination Of Adenovirus Concentration Using Surface Plasmon Resonance 9/10/2018

    The performance of two assays for determination of adenovirus concentration based on surface plasmon resonance (SPR) is demonstrated in this application note.

  6. Purifying Tagged Proteins Using ÄKTA Go Protein Purification System 2/3/2020

    ÄKTA go is a small and compact liquid chromatography system that allows researchers to perform routine protein purification with ease while allowing for efficient use of bench and cold cabinet space.

  7. Effective Downstream Purification For A Clinical-Stage Retrovirus-Like Particle 10/7/2019

    Purification of enveloped viruses and virus-like particles is challenging due to their size and complexity. This study demonstrates resin screening, process development and scale-up purification approaches. 

  8. Why Invest In Emerging Markets Now 10/10/2018

    Unexplored and emerging markets are an attractive prospect for biopharma companies looking to expand. But when it comes to ensuring success, what’s the wisest way to invest?

  9. A Model System For Fast Screening Of Optimal Protein Purification Conditions 6/3/2019

    This study highlights a model system for screening optimal protein purification conditions on a mixed-mode cation exchange resin using a statistical software–generated design of experiment model.

  10. Biopharma’s Talent Crunch: How To Gain And Retain Skilled Labor 8/23/2018

    What strategies should your company consider for recruiting, training, and retaining qualified candidates in order to remain competitive in a burgeoning biopharma market?