Biosimilar App Notes & Case Studies

  1. Impact Of A Chemically Defined Medium For Vero Cells Cultivation And Virus Production For Vaccine Applications 4/9/2021

    In the race to create serum-free, chemically defined media, research efforts have focused on identifying the elements required for superior growth performance. This include growth factors, hormones, carrier proteins, lipids, transition metals, vitamins, polyamines, and adhesion factors. This application note describes 4Cell® NutriVero™ Flex 10, a new Vero cell medium that is serum-free, chemically defined, and animal component-free. 4Cell® NutriVero™ Flex 10 delivers performance that matches conventional media with undefined hydrolysate supplementation.

  2. High-Quality Chromatography System Meets Predesigned DeltaV For Integrated Manufacturing 3/9/2021

    Cytiva’s pre-defined automation solution, Figurate™️, is now available as a turnkey solution by combining our industry-leading ÄKTA™️ process chromatography system with the reliability of the DeltaV DCS platform.

  3. A Multi-Scale Approach To CHO Media Benchmarking 4/9/2021

    Competitive commercial CHO processes demand a balanced combination of media, process and production clone to achieve optimal performance. The aim of this study was to apply a multi-scale approach to efficiently screen combinations of chemically defined commercial media and various CHO production clones using benchtop bioreactor systems.

  4. Overcoming Cell Therapy Supply Chain Challenges 5/11/2021

    To ensure the industry can realize the potential of cell and gene therapies, we must develop improved solutions that reliably support the control and transport of critical CGT raw materials and products.

  5. Automated High Throughput mAb Purification Using Fibro Technology 4/21/2020

    Read how the Fibro PrismA unit provides a time advantage with comparable recovery and product quality attributes to resin-based column.

  6. EDGE Confocal Imaging Technology 10/9/2019

    Increasingly, scientists are being challenged to study more biologically-relevant model systems, and this often means imaging thick, demanding 3D samples that may also be alive. Read how IRIS and EDGE confocal imaging can offer high contrast imaging of thicker samples.

  7. Developing A Closed Connected Single Use mAb Purification Process 9/28/2020

    This article provides an overview of a successfully designed closed and physically connected mAb process at the pilot scale with single-use components.

  8. Best Practices For A Successful Bioprocess Technology Transfer 9/10/2019

    A well-executed bioprocess technology transfer is critical to ensure smooth knowledge transfer and optimal process reproducibility. 

  9. Enabling Broader Adoption Of Process Intensification In Biopharma 7/9/2021

    PI is becoming increasingly well-understood and its utility is continuously evolving to meet specific manufacturer needs, from product development to manufacturing, whether approached stepwise or end-to-end.

  10. Reducing Cost Of Goods For Gene Therapy 7/24/2020

    Frost & Sullivan's Virtual Think Tank brought together leading minds to discuss key challenges and other insights related to reducing the cost of goods (COGs) for gene therapy.