Biosimilar App Notes & Case Studies

1. How Biogen Integrated PAT With End-To-End Supply Chain Transparency 10/2/2018

   To drive dependable critical process control requirements, Biogen explored novel strategies to increase process and raw material control and optimize communication of data throughout the supply chain.

2. Making The Business Case For Vaccine Manufacturing 10/10/2018

   Vaccines are absolutely crucial for maintaining global health, but are a challenge to develop and manufacture. How can businesses ensure profitability while providing low prices for developing countries?

3. A Model System For Fast Screening Of Optimal Protein Purification Conditions 6/3/2019

   Identifying optimal purification conditions can require time consuming evaluation of many parameters.This study highlights a model system for screening optimal protein purification conditions on a mixed-mode cation exchange resin using a statistical software–generated design of experiment model.

4. Quick Purification Strategy: Adenovirus Purification 6/11/2018

   Adenoviruses are commonly used as gene transfer vectors in gene therapy and clinical trials. However, their large size, complexity, and acid labile nature lead to challenges in their downstream purification.

5. How Services Marketers Can Own Their Performance Measures 1/29/2019

   Service marketers can take control of their marketing performance by implementing credible marketing effectiveness measures and creating their own narrative.

6. Purification Of Antibodies With Hydrophobic Anion Exchange Resin 9/11/2019

   A hydrophobic anion exchange mixed-mode resin has been developed to overcome challenges in antibody purification. This application note describes the purification of acidic and basic antibodies using this mixed-mode chromatography resin through bind-elute and flow-through modes of purification.

7. Automated In-Line Buffer Prep Saves Time And Facility Footprint 2/1/2018

   Buffer preparation is both time- and space-consuming and become a challenge in biomanufacturing. This application note describes a lean approach to buffer preparation by implementing in-line conditioning.

8. Fujifilm Diosynth Biotechnologies Drives Flexibility And Efficiency In Their Biomanufacturing Platform Using Integrated Automation 8/30/2018

   Through a successful implementation, Fujifilm was able to not only recognize the benefits an integrated automation platform offers but also the importance of working with an experienced partner.

9. The Transparent CDMO: Maintain Autonomy In Biomanufacturing Partnership 7/6/2018

   Complete transparency and open communication are both critical for a successful partnership. What business practices should you look for to ensure your CDMO can offer this type of commitment?

10. End-To-End Process For Oncolytic Adenovirus Production 3/20/2019

    Oncolytic viruses constitute a new promising therapeutic approach for treatment of cancer. Here’s an example of a scalable, end-to-end process for oncolytic adenovirus production using modern tools and technologies.