Biosimilar App Notes & Case Studies

  1. Lifetime Performance Study Of MabSelect™ PrismA During Repeated Cleaning‑In‑Place Cycles

    A demonstration of the long‑term chromatographic performance of MabSelect PrismA during repeated purification cycles using 0.5 M NaOH for CIP.

  2. Transforming Cancer Research: Digital PCR Technology Plays Integral Role At Cancer Research Center

    How  digital PCR technology is helping scientists in their quest to break through the current limits of nucleic acid detection and quantification.

  3. Quantitating Binding Similarities In IgG Fcγ Receptor Analysis

    Critical quality attributes are fundamental to regulatory compliance in drug development and manufacturing. Learn how surface plasmon resonance has been applied for protein characterization of antibody effector function.

  4. Process-Economy Simulation Of mAb Capture Step With Protein A Chromatography Resin

    Calculation examples that highlight scenarios where the enhanced capacity and alkaline‑stability of MabSelect PrismA can provide process economic benefits to large‑scale mAb processing.

  5. Purification Of Antibodies With Hydrophobic Anion Exchange Resin

    A hydrophobic anion exchange mixed-mode resin has been developed to overcome challenges in antibody purification. This application note describes the purification of acidic and basic antibodies using this mixed-mode chromatography resin through bind-elute and flow-through modes of purification.

  6. Prepare For An FDA Bioburden Inspection

    A former FDA Biologics License Application reviewer and inspector focusing on microbiology, shares expert tips on how to best approach a bioburden problem when an FDA inspection is imminent.

  7. Purification Of An Acidic IgM For Large Biomolecule Purification

    The large size of IgMs makes their purification very challenging. See how Bio-Rad's new strong anion exchange resin (AEX), Nuvia HP-Q, has the ability to overcome the multiple issues faced when purifying large biomolecules.

  8. Improved Method for Determination of Adenovirus Concentration Using Surface Plasmon Resonance

    The performance of two assays for determination of adenovirus concentration based on surface plasmon resonance (SPR) is demonstrated in this application note.

  9. Stripping And Reprobing Western Blot Membrane: Problems And Solutions

    Ways of maximizing your Western blot membrane use by stripping and reprobing with another primary antibody.

  10. Embracing Biosimilars, They Are Here To Stay

    The biosimilars market is suddenly booming, with established biopharma giants and nimble start-ups all clamoring for a piece of the action. But such steep competition means that only the wise will survive.