Biosimilar App Notes & Case Studies

1. Purifying Plasmid DNA Using A Modern Chromatography Resin 2/5/2020

   Through an industry collaboration, Cobra and GE were able to combine their expertise and experience and create a solution to meet the rising demand for high quality plasmid DNA.

2. Adenovirus Production In Single-Use Xcellerex™ XDR-10 Bioreactor System 9/10/2018

   This application note describes the production of adenovirus in HEK293 cells cultured in HyClone™ CDM4HEK293 culture medium.

3. Don't Sacrifice Yield For Purity In Downstream Purifications 6/5/2019

   This resin optimizes the balance of ion exchange and hydrophobic interactions to deliver simultaneous purity and yield of therapeutic proteins and monoclonal antibodies that are typically difficult to purify.

4. How Biogen Integrated PAT With End-To-End Supply Chain Transparency 10/2/2018

   To drive dependable critical process control requirements, Biogen explored novel strategies to increase process and raw material control and optimize communication of data throughout the supply chain.

5. Expanded Droplet Digital PCR Multiplexing Capability Using Two Different Strategies 10/23/2019

   Droplet Digital PCR (ddPCR) enables easy multiplexing of numerous targets within each fluorescent channel. Amplitude-based multiplexing achieves this by varying primer and/or probe concentrations. In probe-mixing multiplexing, probes are mixed at desired concentrations to place targets in a defined position on a 2-D plot. This paper describes strategies for both approaches using the large portfolio of ddPCR Assays readily available through Bio‑Rad.

6. Amgen’s Digital Transformation: Link Suppliers' Raw Material Data To Patients 10/19/2018

   Using its Supplier Relationship Excellence program, Amgen opened the lines of communication with suppliers and created a feedback loop where data can be shared to optimize operational performance. 

7. Biopharma’s Talent Crunch: How To Gain And Retain Skilled Labor 8/23/2018

   What strategies should your company consider for recruiting, training, and retaining qualified candidates in order to remain competitive in a burgeoning biopharma market?

8. The Transparent CDMO: Maintain Autonomy In Biomanufacturing Partnership 7/6/2018

   Complete transparency and open communication are both critical for a successful partnership. What business practices should you look for to ensure your CDMO can offer this type of commitment?

9. Modular Approaches For Diverse Molecules: Reinventing Smart Bioprocessing 2/23/2018

   Smart bioprocessing uses bioinformatics, lab-scale processing, and analytics to create efficient and cost-effective production processes that can be verified at lab-scale before scale-up.

10. Securing Bioprocess Film Supply 7/9/2019

    Learn how a partnership built on technical expertise and trust is helping to secure the supply of a single-use film built for bioprocessing.