Vaccines are absolutely crucial for maintaining global health, but are a challenge to develop and manufacture. How can businesses ensure profitability while providing low prices for developing countries?
Identifying optimal purification conditions can require time consuming evaluation of many parameters.This study highlights a model system for screening optimal protein purification conditions on a mixed-mode cation exchange resin using a statistical software–generated design of experiment model.
Adenoviruses are commonly used as gene transfer vectors in gene therapy and clinical trials. However, their large size, complexity, and acid labile nature lead to challenges in their downstream purification.
A hydrophobic anion exchange mixed-mode resin has been developed to overcome challenges in antibody purification. This application note describes the purification of acidic and basic antibodies using this mixed-mode chromatography resin through bind-elute and flow-through modes of purification.
Buffer preparation is both time- and space-consuming and become a challenge in biomanufacturing. This application note describes a lean approach to buffer preparation by implementing in-line conditioning.
Oncolytic viruses constitute a new promising therapeutic approach for treatment of cancer. Here’s an example of a scalable, end-to-end process for oncolytic adenovirus production using modern tools and technologies.