Biosimilar App Notes & Case Studies

1. Genomic Medicine And The Tools To Realize Its Potential 1/12/2022

   New technologies and collaborations driving the democratization of RNA therapeutics are creating an explosion of opportunity for companies pursuing the development of these transformative medicines.

2. Achieving Business Continuity In Pharma During COVID-19 Restrictions 3/4/2021

   To ensure business continuity during COVID-19 restrictions, we developed a virtual factory acceptance testing solution that allowed SaudiVax to advance their manufacturing plan.

3. Process Development For AAV Vector Production In Suspension Cells 11/19/2021

   Review experiments for the adaptation of the HEK293 suspension cell line for transient transfection and scalable adeno-associated virus (AAV) production.

4. 3 Steps To Optimize The Fed-Batch Process For mAb Production 6/2/2021

   We describe a straightforward way to achieve high-performing fed-batch process for a knockout cell line. This workflow improved titers 500% compared with CHO cell culture in basal medium.

5. Explore Protein Interactions Beyond Affinity To Boost Your Academic Research 7/20/2022

   Explore how you can simplify research on protein-protein interactions using our SPR systems.

6. Viral Vector Scale-Up: How Can We Bridge The Technology Gaps? 4/15/2021

   Unlocking the full potential of viral-vector based therapies requires an understanding of existing challenges in viral vector production and what technologies are now available to help address them.

7. Purifying Infectious Virus Particles Using ÄKTA™ Start 5/20/2021

   This application note demonstrates a chromatography method for purifying reovirus RNA virus particles using a benchtop chromatography system, HiTrap brand columns, and Capto brand Core 700 resin.

8. Transition To Closed Processing Systems 10/12/2022

   Learn about our transition to closed processes for expansion of suspension CHO and Sf9 cells and how the closed system compares to traditional processing.

9. Improve Bioprocessing Efficiency With A Standardized Automation Platform 3/9/2021

   Designed specifically for the biomanufacturing industry, Cytiva's Figurate automation is a portfolio of automation platform solutions powered by the reliability of Emerson’s DeltaV.

10. AAV Production In Suspension HEK293 Cells With Single-Use Bioreactors 10/13/2022

    Explore how we expanded HEK293/HEK293T suspension cells from small cell culture (20 mL) in shake flasks up to a 10 L culture in a benchtop Xcellerex™ XDR-10 single-use bioreactor system.