Biosimilar App Notes & Case Studies
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Implementing High Cell Density Cryopreservation In Your Seed Train
1/22/2023
Simplify seed train intensification with high cell density cryopreservation. Eliminate the need for manual scale-up steps and enable risk reduction through closed banking and inoculation processes.
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Exosome Isolation By TFF And Size Exclusion Chromatography
3/6/2024
Here, we demonstrate a scalable workflow for the isolation of exosomes that combines tangential flow filtration for the concentration of exosomes followed by gentle size exclusion chromatography.
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Automated Cell Washing And Formulation In CAR T Cell Therapy Manufacturing
6/14/2024
Explore data collected from a study utilizing healthy donors in a typical CAR T cell processing workflow without a transduction step from a cross-site validation study.
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AAV Full/Empty Capsid Separation Using Mechanistic Modeling
5/1/2023
In this study, we used mechanistic modeling to investigate how AAV-resin interactions are affected when MgCl2 is used as an elution additive.
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Scalability And Performance Of Single-Use Bioreactors
8/1/2023
Here, we provide scalability data as a guide for process development and cross-scale performance expectations and characterize performance attributes of the impeller, spargers, Ultimus® film, and sensors.
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Establishing A Robust Workflow To Identify High-Performing Clones
1/13/2023
Cell line development is a complex, labor intensive, and multistep process. Learn about a platform and host cell line that minimize the risk and timeline to develop high-performing clones.
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Media And Buffer Mixing Using The Xcellerex™ Magnetic Mixer
6/19/2024
A common requirement for media and buffer preparation in biopharma processing is powder-liquid mixing. Review the performance of a 3000 L single-use mixing system for preparing aqueous solutions.
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TFF Cassettes With 100 kDa Membranes For RNA And LNP Applications
7/3/2024
Explore data showcasing the performance of regenerated cellulose flat sheet membranes with a 100 kDa molecular weight cutoff for UF/DF of RNA molecules by TFF.
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Raman As A Quality Control Tool For Cell Culture Media Preparation
6/14/2024
Explore study results demonstrating how Raman technology easily differentiates between media with similar compositions and detects potential preparation errors that other analysis methods might miss.
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Accelerating Bulk Harvest Release Testing With A PCR-Based Solution
7/3/2024
Adventitious agent testing is frequently a bottleneck in downstream processing. Discover a PCR-based solution for manufacturing processes using CHO cells and animal origin-free components.