Biosimilar App Notes & Case Studies

1. Establishing A Robust Workflow To Identify High-Performing Clones 1/13/2023

   Cell line development is a complex, labor intensive, and multistep process. Learn about a platform and host cell line that minimize the risk and timeline to develop high-performing clones.

2. Alkaline Stability Of Fc And VH3 Binding In Protein A Resins 5/1/2023

   In this study, we looked at how different antibody binding sites of a protein A ligand are affected by cleaning in place (CIP).

3. Depth Filtration Devices For Cell Cultures, Fermentation Broths, And Cell Lysates 3/27/2023

   Typically, devices containing depth media filters can offer more efficient filtration. Browse depth filtration products and devices for the downstream processing of cell culture solutions, fermentation broths, and lysates.

4. Recombinant Adeno-Associated Virus Type 5 Production Process 10/12/2022

   Learn about a scalable process for the production of rAAV using triple plasmid transfection of suspension cells in an animal-derived component-free medium.

5. Optimizing Recovery On The Sepax™ Cell Processing System 7/21/2022

   Using a model T-cell line, we demonstrate the impact of varying rinse volume, intermediate volume, and manual extraction parameters on overall cell recovery with a final product dose volume of 20 mL.

6. Maximize Product Recovery In Bulk Filtration And Filling Flow Paths 12/15/2022

   Explore a fill system designed to automate product draining and recovery within a batch to standardize processes and minimize non-recoverable hold-up within the filtration and distribution flow path sections.

7. Genomic Medicine And The Tools To Realize Its Potential 1/12/2022

   New technologies and collaborations driving the democratization of RNA therapeutics are creating an explosion of opportunity for companies pursuing the development of these transformative medicines.

8. AAV Full/Empty Capsid Separation Using Mechanistic Modeling 5/1/2023

   In this study, we used mechanistic modeling to investigate how AAV-resin interactions are affected when MgCl₂ is used as an elution additive.

9. TFF For Laboratory And Process Development Applications 3/1/2023

   Learn about the basic principles that govern tangential flow filtration (TFF) along with the use of TFF capsules and cassettes in laboratory and process development applications.

10. Enabling Bioprocess Control With Successful Automation Strategies 12/9/2021

    In a recent live event with Bioprocess Online, industry experts at various stages of their automation journey discussed their approach to enhancing quality control and data integrity through automated technologies.