Biosimilar App Notes & Case Studies

1. How To Successfully Isolate Your T Cells 10/7/2024

   Explore the results of a study focusing on the early stages of the CAR T cell workflow, specifically the initial washing of leukapheresis followed by the isolation of T cells.

2. Scalable rAAV9 Production Using Advanced Cell Lines And Bioreactors 6/15/2026

   Progress in gene therapy manufacturing is being driven by improved cell line performance and scalable bioprocessing. See how high-density growth helps streamline development to larger-scale production.

3. Efficient Protein Purification Strategies 2/24/2026

   Examine two rapid, high‑throughput strategies for small‑scale protein separation, using either multimodal resins or ion exchange membranes to achieve efficient, low‑volume purification.

4. Replicate Bioscience And Cytiva Collaborate To Deliver srRNA-LNP Vaccines 3/24/2025

   Discover how self-replicating RNA (srRNA) can revolutionize vaccine development with sustained protein expression, lower doses, and fewer side effects to advance next-gen RNA therapeutics.

5. Cell Culture Media Filtration: Evaluating Cell Culture Performance 10/23/2025

   Cell culture performance remained consistent across PES and PVDF filters, even under worst-case filtration conditions. Discover a practical framework for evaluating membrane impact on CHO cell growth.

6. Evaluating Antibody Fragment Purification Using VH3 Resin 5/22/2026

   Explore how VH-domain targeting enables efficient purification of VH3 antibody fragments and bispecific formats, with strong recoveries and flexible wash conditions that support improved purity.

7. Reducing Plastic Waste Using Syringeless Filters 2/25/2026

   A streamlined approach to HPLC sample preparation can cut plastic waste by up to 79%. Find out how reducing consumables simplifies workflows and supports more sustainable, efficient lab operations.

8. Process Intensification Through Downstream Connectivity 7/1/2026

   See how downstream steps can be linked into a coordinated workflow, with practical insight into automation, equipment integration, and process control for building a more efficient strategy.

9. Controlling mAb Aggregates In Chromatography Process Development 5/22/2026

   Antibody aggregation remains a critical downstream challenge, particularly for complex modalities. Explore why aggregates form, why they matter, and how chromatographic strategies can help reduce risk.

10. Oligonucleotide Purification And Synthesis 1/27/2026

    Examine how a 21‑mer oligo was synthesized and purified through systematic resin screening, method optimization, and successful scale‑up to build reliable, high‑purity chromatography workflows.