Biosimilar App Notes & Case Studies
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Accelerating Bulk Harvest Testing Using A CHO Animal Origin Free Virus Panel
10/19/2023
Here, we describe the design and performance of a degenerate PCR-based approach to broad virus screening that can be used in testing bulk harvest material derived from CHO cells.
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Aseptic Filling Solution Enhances Sterility Assurance for Pharma Manufacturer
11/21/2024
Emergent BioSolutions upgraded its Winnipeg site with the Cytiva SA25 aseptic filling workcell to improve sterility assurance, product flexibility, and regulatory compliance for CGT manufacturing.
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Mobius® ADC Reactor Performance
10/22/2024
Learn about a family of single-use ADC reactors that has been developed to offer a safer and more efficient ADC production method than traditional mixing systems and meet the industry's growing needs.
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A Transient Cell Line To Produce rAAV With Low-Level hcDNA Encapsidation
1/15/2025
Discover the ability of a novel HEK293 suspension cell line for efficient and scalable rAAV production across various serotypes with low encapsidated host cell DNA levels.
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Real-Time And In-Line Raman Spectroscopy For Glycan Quality Analysis
6/14/2024
This study details the use of in-line Raman spectroscopy to monitor mAb glycan profiles within a production bioreactor, highlighting its potential for automation and customization.
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Demonstrated Strength And Durability Of Ultimus® Film
5/12/2023
Here, we outline the development of Ultimus® film and summarize the strength and robustness tests conducted in accordance with the American Society for Testing and Materials (ASTM).
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How To Successfully Isolate Your T Cells
10/7/2024
Explore the results of a study focusing on the early stages of the CAR T cell workflow, specifically the initial washing of leukapheresis followed by the isolation of T cells.
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Production Of A Highly Concentrated Monoclonal Antibody
10/4/2024
The production of a highly concentrated monoclonal antibody requires many process steps. Discover how to achieve a final mAb concentration above 200 g/L while maintaining critical quality attributes.
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Exosome Isolation By TFF And Size Exclusion Chromatography
3/6/2024
Here, we demonstrate a scalable workflow for the isolation of exosomes that combines tangential flow filtration for the concentration of exosomes followed by gentle size exclusion chromatography.
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Media And Buffer Mixing Using The Xcellerex™ Magnetic Mixer
6/19/2024
A common requirement for media and buffer preparation in biopharma processing is powder-liquid mixing. Review the performance of a 3000 L single-use mixing system for preparing aqueous solutions.