Biosimilar App Notes & Case Studies

  1. Multidimensional Scale-Up Of A mAb Capture Step Contributes To Shortened Time To Market 10/10/2018

    This application note demonstrates a multidimensional scale-up (change of both column diameter and bed height) of a mAb capture step, using the ÄKTA pilot 600 chromatography system.

  2. Modular Bioprocessing Alleviates Drug Manufacturing Woes 4/4/2019

    Building a bioprocessing facility is usually a complicated process and requires partnering with not only drug developers, but also many different experts in various industries.

  3. Optimization Of Midstream Cell Lysis And Virus Filtration Steps In An Adenovirus Purification Process 9/10/2018

    Here we describe screening of detergents for release of adenovirus from HEK293 host cells to replace the traditionally used detergent Triton™.

  4. Scale-Up Of CHO Cell Fed-Batch Cultures In HyClone ActiPro Medium Supplemented With Cell Boost 7a And 7b 2/21/2020

    This note compares cell growth and recombinant protein production of multiple Chinese hamster ovary cell clones when cultured in HyClone ActiPro basal medium and Cell Boost 7a and 7b feeding supplements.

  5. Balancing Stainless, Single-Use, And Continuous Manufacturing 9/21/2018

    Several drivers affect how the appropriate facility design and unit operations for a process are selected, making it imperative to properly evaluate each option. 

  6. 6 Reasons You Don’t Use Pharmaceutical Market Research 2/28/2020

    If you're using one of these six excuses for ignoring pharma market research, you're failing to understand barriers to success, missing the market’s perspective, and leaving assumptions unvalidated.

  7. How Services Marketers Can Own Their Performance Measures 1/29/2019

    Service marketers can take control of their marketing performance by implementing credible marketing effectiveness measures and creating their own narrative.

  8. Capacity And Performance Of MabSelect™ PrismA Protein A Chromatography Resin 10/2/2018

    This application note demonstrates the binding capacity of MabSelect PrismA in comparison with its predecessor products for both polyclonal and monoclonal antibodies.

  9. Purposeful Design, Development Of Next-Gen Single-Use Bioprocess Film 8/7/2019

    Cytiva's investment in Fortem film development will help meet industry need for a fully-characterized platform film for bioprocessing applications, with supply chain transparency as a focal point. 

  10. Optimizing Cell Culture Media To Increase Cell Culture Titer With Maintained Protein Quality 2/21/2020

    When evaluating media with the goal of increasing titers, it is important to ensure that protein quality is not negatively impacted. So how can this process improvement be performed reliably? It makes sense to use a Design of Experiments (DoE) and empirical approach. Here is an example of how to do it.