Biosimilar App Notes & Case Studies

1. Capture Of Bispecific Antibodies And Removal Of Product-Related Impurities 11/17/2022

   Many antibody variants are prone to aggregation or to forming product-related impurities. Explore the application of a resin with novel selectivity to purify challenging entities.

2. TFF For Laboratory And Process Development Applications 3/1/2023

   Learn about the basic principles that govern tangential flow filtration (TFF) along with the use of TFF capsules and cassettes in laboratory and process development applications.

3. In-House Manufacturing: Key To Driving A Diabetes Vaccine? 1/28/2022

   Increasing constraints on today’s supply chain from the COVID-19 pandemic mean drug companies must secure strategies that can ensure product delivery in the face of these challenges.

4. Forecasting The Integrity Of The Biopharma Supply Chain 6/30/2021

   Receiving customer forecasts as early and completely as possible is critical to the success of the supply chain continuum.

5. Process Development For AAV Vector Production In Suspension Cells 11/19/2021

   Review experiments for the adaptation of the HEK293 suspension cell line for transient transfection and scalable adeno-associated virus (AAV) production.

6. Streamlining The Integrity Testing Process – From Test To Report 2/22/2023

   Discover a digital transformation solution that provides first of its kind data analytics for filter integrity testing. The software helps operators and supervisors reduce time lost through review processes.

7. Generating A Robust Host Cell Line For A Cell Line Development Platform 11/14/2022

   Learn how cell performance within the context of the cell line development workflow was confirmed with the successful isolation of stable, high-producing clones from three model monoclonal antibodies.

8. Genomic Medicine And The Tools To Realize Its Potential 1/12/2022

   New technologies and collaborations driving the democratization of RNA therapeutics are creating an explosion of opportunity for companies pursuing the development of these transformative medicines.

9. Designing Successful Viral Clearance Studies 12/23/2021

   A review of studies which involve scaling down individual process steps, and for each step, spiking virus into the specific process intermediate, performing the process step and measuring the remaining virus.

10. The Importance Of CDMO Capacity For Viral Vectors: A Conversation With Forge’s Dr. Timothy Miller 10/4/2021

    In this episode of The Business of Biotech, Forge Biologics' Dr. Timothy Miller talks about the importance of increasing specialized CDMO capacity for cell and gene therapy applications.